Generalized joint hypermobility 

Skin findings (mildly stretchy skin, abnormal scars, soft skin) 

Tissue fragility (hernias, pelvic prolapse, heel papules)

Pain or joint instability 

Arterial rupture at young age (aneurysm, dissection of artery)

Spontaneous rupture of sigmoid colon

Uterine rupture in pregnancy

Carotid-Cavernous sinus fistula formation 

Severe and progressive cardiac-valvular problems

Skin changes (stretchy skin, atrophic scars, easy bruising)

Hypermobile joints 

Extreme skin fragility

Very lax/loose skin 

Severe, easy bruising

Abnormal facial features 

Thin cornea with or without rupture

Early onset progressive keratoconus or keratoglobus

Blue Sclerae

Congenital joint contractures or clubfoot

Characteristic facial features 

Abnormal skin findings (stretchy skin, easy bruising, fragile skin with atrophic scaring)

Severe and intractable periodontitis of early onset

Lack of attached gingiva

Pretibial plaques

Very stretchy skin 

Atrophic scarring

Generalized joint hypermobility 

Very stretchy skin

Generalized joint hypermobility

Abnormally easy bruising

No abnormal scarring 

Congenital (being born with) both hips dislocated 

Severe generalized joint hypermobility 

Stretchy skin 

Low muscle tone at birth

Early onset/congenital  kyphoscoliosis 

Generalized joint hypermobility with joint instability 

Short stature (progressive in childhood)

Low muscle tone

Bowing of limbs 

Low muscle tone at birth and/or muscle atrophy which improves with age

Joint contractures

Hypermobility of small joints