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Classical EDS 

DNA Strand

Caused by genetic variants in the COL 5A1, COL 5A2 and rarely the COL 1A1 genes

DNA Strand

Main features include significant skin hyperextensibility, atrophic scarring, skin fragility, joint hypermobility and joint instability 

DNA Strand

Affects approximately

1/20,000 - 1/40,000 people

  • There is no cure of Classical EDS and management should focus on managing individual symptoms.      

  • Joint and skin protection as well as avoidance of trauma are important management strategies. 

  • Patient with Classical EDS will benefit from the care of the multidisciplinary GoodHope EDS team. 

Vascular EDS 

DNA Strand

Caused by genetic change to the COL 3A1 gene

DNA Strand

Common features include arterial aneurysm, dissection and rupture, bowel or uterine rupture, thin translucent skin, very easy bruising and characteristic facial appearance

DNA Strand

Affects approximately 1/50,000 - 1/200,000 people 

  • There is no cure for Vascular EDS and treatment should focus on risk avoidance, regular vascular screening, blood pressure maintenance, and treatment of underlying symptoms/health issues.

  • The GoodHope EDS clinic can provide assessment, diagnosis and support for patients with Vascular EDS.  

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