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Classical EDS (cEDS)

- cEDS is caused by genetic variants in the following genes: COL5A1, COL5A2, COL1A1

- Main features include significant skin hyperextensibility, atrophic scarring, skin fragility, joint hypermobility and joint instability.  

- cEDS affects approximately 1 in 20,000 - 40,000 people

- There is no cure of cEDS and management should focus on managing individual symptoms.           -Joint and skin protection as well as avoidance of trauma are important management                 strategies 

- Patient with cEDS will benefit from the care of the multidisciplinary GoodHope EDS team 

Vascular EDS (vEDS)

- vEDS is caused by genetic variants at COL3A1 

- vEDS affects 1/50,000 - 1/200,000

- Common features are arterial aneurysm, dissection and rupture, bowel rupture and uterine rupture

- There is no cure for vEDS and treatment should focus on risk avoidance, regular vascular screening, blood pressure maintenance, and treatment of underlying symptoms/health issues

- The GoodHope EDS clinic can provide assessment, diagnosis and support for patients with vEDS  

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